PLACENTAL NOREPINEPHRINE TRANSPORTER: EXPRESSION AND REGULATION.† 331
نویسندگان
چکیده
منابع مشابه
Regulation of the human norepinephrine transporter by cocaine and amphetamine.
Certain antidepressant and psychostimulant drugs block the uptake of norepinephrine from the synaptic cleft by inhibiting norepinephrine transporter (NET) function. The effects of chronic occupation of the NET by these drugs on NET expression are poorly understood. We previously described down-regulation of the NET in cultured cells after continuous exposure to the tricyclic antidepressant desi...
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Although glucocorticoids play important roles in development and fetal programming, they are widely used for treatment of a variety of diseases during pregnancy. In various tissues, glucocorticoids downregulate glucose transport systems; however, their effects on glucose transporters in the placenta are unknown. In the present study, the glucose carrier proteins GLUT1 and GLUT3 were localized i...
متن کاملHuman placental taurine transporter in uncomplicated and IUGR pregnancies: cellular localization, protein expression, and regulation.
Transplacental transfer is the fetus' primary source of taurine, an essential amino acid during fetal life. In intrauterine growth restriction (IUGR), placental transport capacity of taurine is reduced and fetal taurine levels are decreased. We characterized the protein expression of the taurine transporter (TAUT) in human placenta using immunocytochemistry and Western blotting, tested the hypo...
متن کاملThe Human Placental Taurine Transporter in Uncomplicated and IUGR Pregnancies: Cellular Localization, Protein Expression and Regulation
Transplacental transfer is the fetus’ primary source of taurine, an essential amino acid during fetal life. In intrauterine growth restriction (IUGR) placental transport capacity of taurine is reduced and fetal taurine levels are decreased. We characterized the protein expression of the taurine transporter (TAUT) in human placenta using immunocytochemistry and Western blotting, tested the hypot...
متن کاملPlacental glucose transporter gene expression and metabolism in the rat.
In situ hybridization was used to evaluate patterns of gene expression for glucose transporters 1-4 (GT1-4) in the rat uteroplacenta from the time of implantation through term, and in vivo regional placental glucose metabolism was measured by 14C-labeled 2-deoxyglucose uptake. GT1 mRNA was highly abundant and GT3 was barely detected in the postimplantation decidual reaction. GT1 and 3 mRNAs wer...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199604001-00351